January 2012 archive

Big Profits For Big Pharma

Cross posted from The Stars hollow Gazette

From 2000 to 2009, Pharmaceutical companies reaped $690 billion in mergers and only invested 10% of that on research to find cures for 90% of the world’s diseases. The Unites States rank #1 in the amount that is spent on health care but only #37 when it comes to the quality of that care.

Author and medical ethicist, Harriet A. Washington’s recent book “Deadly Monopolies”, delves into the corporate takeover of the medical industry that is affecting the healthcare system and the future of medicine. The book also examines the role of medical patents in slowing U.S. research and inflate drug costs. Ms. Washington joined Dylan Ratigan and his panel to discuss “Big Pharma” and big profits.

Deadly Monopolies

You can read an adapted exert from “Deadly Monopolies” here

One of the diseases and its cure that it touched upon in this discussion is Human African trypanosomiasis HAT, or sleeping sickness. Second stage sleeping sickness is treated with eflornithine, which is given in 4 intravenous infusions daily for 14 days.

A little side story of Eflornithine and the fight that WHO and an NGO waged to get it produced. The drug was originally developed as a cancer treatment by Merrell Dow Research Institute in the late ’70’s. It wasn’t very effective as a cancer treatment but was found to reduce hair growth and, inadvertently, very a effective treatment for HAT. Eventually, it was developed and marketed as a prescription cream, Vaniqa, to treat women with excessive facial hair by the Gillette company.

The drug was registered for the treatment of gambiense HAT in 1990. However, in 1995 Aventis (now Sanofi-Aventis) stopped producing the drug, whose main market was African countries, because it didn’t make a profit. Production for the drug requires a separate facility because the process is very corrosive.

In 2001, Aventis (now Sanofi-Aventis) and the WHO formed a five-year partnership, during which more than 320,000 vials of pentamidine, over 420,000 vials of melarsoprol, and over 200,000 bottles of eflornithine were produced by Sanofi-Aventis, to be given to the WHO and distributed by the association Médecins Sans Frontières in countries where the sleeping sickness is endemic.

According to Médecins Sans Frontières, this only happened after “years of international pressure”, and coinciding with the period when media attention was generated because of the launch of the eflornithine-based product, Vaniqa, geared to prevention of facial-hair in women), while its life-saving formulation was not being produced.

From 2001, when production was restarted, through 2006, 14 million diagnoses were made. This greatly contributed to stemming the spread of sleeping sickness, and to saving nearly 110,000 lives. This changed the epidemiological profile of the disease, meaning that eliminating it altogether can now be envisaged.  

On This Day In History January 8

Cross posted from The Stars Hollow Gazette

This is your morning Open Thread. Pour your favorite beverage and review the past and comment on the future.

Find the past “On This Day in History” here.

January 8 is the eighth day of the year in the Gregorian calendar. There are 357 days remaining until the end of the year (358 in leap years).

On this day in 1877, Crazy Horse and his warriors–outnumbered, low on ammunition and forced to use outdated weapons to defend themselves–fight their final losing battle against the U.S. Cavalry in Montana.

Six months earlier, in the Battle of Little Bighorn, Crazy Horse and his ally, Chief Sitting Bull, led their combined forces of Sioux and Cheyenne to a stunning victory over Lieutenant Colonel George Custer (1839-76) and his men. The Indians were resisting the U.S. government’s efforts to force them back to their reservations. After Custer and over 200 of his soldiers were killed in the conflict, later dubbed “Custer’s Last Stand,” the American public wanted revenge. As a result, the U.S. Army launched a winter campaign in 1876-77, led by General Nelson Miles (1839-1925), against the remaining hostile Indians on the Northern Plains.

On January 8, 1877, General Miles found Crazy Horse’s camp along Montana’s Tongue River. U.S. soldiers opened fire with their big wagon-mounted guns, driving the Indians from their warm tents out into a raging blizzard. Crazy Horse and his warriors managed to regroup on a ridge and return fire, but most of their ammunition was gone, and they were reduced to fighting with bows and arrows. They managed to hold off the soldiers long enough for the women and children to escape under cover of the blinding blizzard before they turned to follow them.

Though he had escaped decisive defeat, Crazy Horse realized that Miles and his well-equipped cavalry troops would eventually hunt down and destroy his cold, hungry followers. On May 6, 1877, Crazy Horse led approximately 1,100 Indians to the Red Cloud reservation near Nebraska’s Fort Robinson and surrendered. Five months later, a guard fatally stabbed him after he allegedly resisted imprisonment by Indian policemen

Six In The Morning

On Sunday

Blacks in New Orleans cry foul over French Quarter curfew

The City Council says stricter rules are meant to protect kids, but critics accuse members of wanting to keep low-income blacks out of sight of tourists.

By Richard Fausset, Los Angeles Times

Reporting from Atlanta– From a distance, it seemed like common sense: an ordinance meant to keep children away from an open-air night-life zone with more than 350 places to buy booze, an abundance of strip joints and a 300-year-old reputation for iniquity.

But last week, as the New Orleans City Council approved a strict curfew for youths 16 and younger in the French Quarter, it sparked an incendiary debate that laid bare some of the tensions over race and police priorities that the Louisiana city – which suffers from the nation’s highest per capita murder rate – is struggling to resolve as it navigates its post-Hurricane Katrina future.




Sunday’s Headlines:

Syria unrest: Arab League to discuss observer mission

Cambodia’s lost temple, reclaimed from the jungle after 800 years

Burma’s opposition prepares for the unexpected after Aung San Suu Kyi agrees to contest elections

Men of steel revive the heart of Gotham

ANC centenary draws praise from African leaders

Booman wants war with Iran.

 

Eh, ragazzo, I didn’t want to go this way, but we are at war.  Stupid fucking Hobbit.  Stupid fucking man.  

BooMan is pushing the long-ago debunked IAEA report and wishes that the international community squeezes Iran like a balloon to enact regime change.  

And he thinks I’m the moron.  Needless to say, I think such manifest nonsense is crazier than a shithouse rat dining on Dick Cheney’s rotting corpse.  Are you listening, driftglass?  We haven’t even finished our latest war crimes that broke us to pieces.  Suffice it to say, if we attack Iran, I rely upon the noble Persians to shove the Fifth Fleet up our collective ass, for the sake of justice.

Ideological insanity.

I want to touch on the problem of ideological insanity.  It strikes me as a Necker cube problem, wherein people lose their ability to “flip” between ambiguous interpretations of reality.

Allow a brief digression.

Jeff Hawkins, who invented the palm pilot, has an interesting theory of cortical function, as good as any, better even.  Based on the virtual uniformity of structure of the large dinner napkin we call neocortex, as originally noted by Mountcastle, he suggests that the invariable function of the six-layered neocortex is to correlate data, the higher the layer, the higher the level of correlation; such that low-level properties (lines, angles, colors) are correlated in the lowest parts of the hierarchy, whereas high-level concepts (war, peace) are correlated in the highest levels of the large dinner napkin.  To quote Hebb, neurons that fire together wire together, and the cerebral cortex is nothing but a massive hierarchical multivariate analysis.

Yes? So good, so far.

The brain’s three parts (I hold with the “four-parts” people, spare parts excluded) can be sub-divided as far as you want to go, but at Swanson’s considerable eyeblink, it goes “cortex, cerebral nuclei, brainstem,” which suffices for our discussion.  

Within the brainstem are two major parts: the incoming and outgoing processes: sensory inflow (thalamus) and motor outflow (hypothalamus), what you see, what you do; low-level stuff, but stuff that should not be dismissed.

The high-level “CEO” (how I hate that acronym) in the cortex relies on incoming data.  He is only as good as his data.  But what happens over time, learning, development, is that the high-level correlations, i.e., belief-systems, come to dominate sensory input; that is, expectations come to rule, even above incoming facts. The large dinner napkin begins to instruct and bias sensory input.  Quite literally, cortical output dominates sensory input, over time.  To put it simply, religion dominates facts, the ‘cerebral cortex coerces sensory input, in the same way Dick Cheney coerced prisoners at black sites (albeit via the triple-descending outflow of cortex).

Now that is fucked up, but that is the way that it is because it is that way.

Late Night Karaoke

Today on The Stars Hollow Gazette

Due to some technical difficulties and the idiosyncrasies of the Internet, mishima could not bring us his Random Japan. He hopes to be able to return next week, so do we. In the meantime our blog partner davidseth has returned refreshed from his brief Internet hiatus with the wit & wisdom of This Week In The Dream Antilles. Welcome back, davidseth

Regular Features-

These Features-

These Weekly Features-

This is an Open Thread

The Stars Hollow Gazette

The most notorious safe haven for terrorists:

The U.S. Constitution.

WØRD.

Cartnoon

This week’s episodes originally aired January 28, 2005.

Diva Delivery & Castle High, Episodes 17 & 18, Season 2

SHH!

How Many Stephen Colberts Are There?

By CHARLES McGRATH, The New York Times Magazine

Published: January 4, 2012

The new Colbert has crossed the line that separates a TV stunt from reality and a parody from what is being parodied. In June, after petitioning the Federal Election Commission, he started his own super PAC – a real one, with real money. He has run TV ads, endorsed (sort of) the presidential candidacy of Buddy Roemer, the former governor of Louisiana, and almost succeeded in hijacking and renaming the Republican primary in South Carolina. “Basically, the F.E.C. gave me the license to create a killer robot,” Colbert said to me in October, and there are times now when the robot seems to be running the television show instead of the other way around.



A voice-over at the end announced that the commercial had been paid for by an organization called Americans for a Better Tomorrow, Tomorrow, which is the name of Colbert’s super PAC, an entity that, like any other super PAC, is entitled to raise and spend unlimited amounts of soft money in support of candidates as long as it doesn’t “coordinate” with them, whatever that means. Of such super-PAC efforts, Colbert said, “This is 100 percent legal and at least 10 percent ethical.”

Just as baffling as the Iowa corn ads – at least to the uninitiated – were some commercials Colbert produced taking the side of the owners during the recent N.B.A. lockout. These were also sponsored by Americans for a Better Tomorrow, Tomorrow, but they were “made possible,” according to the voice-over, by Colbert Super PAC SHH Institute. Super PAC SHH (as in “hush”) is Colbert’s 501(c)(4). He has one of those too – an organization that can accept unlimited amounts of money from corporations without disclosing their names and can then give that money to a regular PAC, which would otherwise be required to report corporate donations. “What’s the difference between that and money laundering?” Colbert said to me delightedly.

In the case of Colbert’s N.B.A. ads, the secret sugar daddy might, or might not, have been Mark Cuban, the owner of the Dallas Mavericks, who has appeared on the show and whom the ads call a “hero.” We’ll never know, and that of course is the point. Referring to the Supreme Court ruling that money is speech, and therefore corporations can contribute large sums to political campaigns, Colbert said, “Citizens United said that transparency would be the disinfectant, but (c)(4)’s are warm, wet, moist incubators. There is no disinfectant.”



“Aren’t lawyers allowed to have fun?” Potter asked me a few weeks ago, adding that he knew what he was signing up for by appearing on the show. He also said he thought that Colbert was serving a useful function. “I’m very careful not to ascribe motive to him – he can speak for himself,” he said. “I don’t know what he’s thinking. He can find the laws ironic or funny or absurd. But he’s illustrating how the system works by using it. By starting a super PAC, creating a (c)4, filing with the F.E.C., he can bring the audience inside the system. He can show them how it works and then leave them to conclude whether this is how it ought to work.”

Sponsored by Americans for a Better New York Times Magazine Tomorrow, Today.

On this Day In History January 7

Cross posted from The Stars Hollow Gazette

This is your morning Open Thread. Pour your favorite beverage and review the past and comment on the future.

Find the past “On This Day in History” here.

January 7 is the seventh day of the year in the Gregorian calendar. There are 358 days remaining until the end of the year (359 in leap years).

On this day in 1789, the first US presidential election is held.  The United States presidential election of 1789 was the first presidential election in the United States of America. The election took place following the ratification of the United States Constitution in 1788. In this election, George Washington was elected for the first of his two terms as President of the United States, and John Adams became the first Vice President of the United States.

Before this election, the United States had no chief executive. Under the previous system-the Articles of Confederation-the national government was headed by the Confederation Congress, which had a ceremonial presiding officer and several executive departments, but no independent executive branch.

In this election, the enormously popular Washington essentially ran unopposed. The only real issue to be decided was who would be chosen as vice president. Under the system then in place, each elector cast two votes; if a person received a vote from a majority of the electors, that person became president, and the runner-up became vice president. All 69 electors cast one vote each for Washington. Their other votes were divided among eleven other candidates; John Adams received the most, becoming vice president. The Twelfth Amendment, ratified in 1804, would change this procedure, requiring each elector to cast distinct votes for president and vice president.

In the absence of conventions, there was no formal nomination process. The framers of the Constitution had presumed that Washington would be the first president, and once he agreed to come out of retirement to accept the office, there was no opposition to him. Individual states chose their electors, who voted all together for Washington when they met.

Electors used their second vote to cast a scattering of votes, many voting for someone besides Adams with Alexander Hamilton less out of opposition to him than to prevent Adams from matching Washington’s total.

Only ten states out of the original thirteen cast electoral votes in this election. North Carolina and Rhode Island were ineligible to participate as they had not yet ratified the United States Constitution. New York failed to appoint its allotment of eight electors because of a deadlock in the state legislature.

Late Night Karaoke

1776 trombones in the pig parade.

There’s a “sanity check” going on over at GOS over the paultons. You gotta love the way they enforce electoral orthodoxy. More better doughnuts. I’m sure Denise Oliver Velez is a regular Scooter Pie in real life, but please, girl, between Glenn and Ian, you so-called “progressive Dems” are not looking wild at heart and weird on top, but rather, pasty in the face, green around the gills, and unbelievably, incredibly hypocritical, to say the least. Does “intellectually jack-booted” go too far? The real argument about Ron Paul has nothing to do with Ron Paul and everything to do with the truth about a certain fascist pig in the White House. Girl-friend wants the soup? Girl-friend can’t handle the soup.

“If you are going to tell people the truth, you had better make them laugh or they will kill you.” –Oscar Wilde

So, two penguins are standing on an ice floe, and one says to the other…

Load more